Understanding the ACE (Angiotensin Converting Enzyme) Serum Test
What It Is:
The ACE (Angiotensin Converting Enzyme) Serum Test measures the level of ACE in your blood. ACE is an enzyme that converts angiotensin I to angiotensin II, which helps regulate blood pressure by causing blood vessels to constrict or narrow2.
This test is commonly used to monitor and diagnose conditions such as sarcoidosis, a disease that causes inflammatory cells called granulomas to form in various organs2.
Why It's Done:
Diagnosing Sarcoidosis:
Helps identify elevated levels of ACE, which are often found in individuals with sarcoidosis2.
Assists in diagnosing other conditions like Gaucher’s disease, which causes fatty substances to build up in cells and internal organs.
Monitoring Health:
Used to monitor the effectiveness of treatment for sarcoidosis and other related conditions2.
Helps evaluate symptoms such as fatigue, fever, unexplained weight loss, night sweats, swollen lymph nodes, joint pain, and dry mouth.
How the Test Works:
Procedure:
A healthcare professional will take a blood sample from a vein in your arm using a small needle2.
The blood sample is collected into a test tube or vial and sent to a laboratory for analysis2.
The procedure is usually quick and relatively painless, with results typically available within a short timeframe2.
Understanding the Results:
Normal Range:
Normal ACE levels typically range from 14 to 82 U/L, but this may vary slightly depending on the laboratory.
Abnormal Findings:
Elevated ACE levels may indicate sarcoidosis, Gaucher’s disease, or other conditions such as cirrhosis, diabetes, HIV, and tuberculosis2.
Low ACE levels may be associated with conditions like chronic obstructive pulmonary disease (COPD), hypothyroidism, and cystic fibrosis.
Why Your Doctor Might Order This Test:
Symptoms of Sarcoidosis:
If you have symptoms such as fatigue, fever, unexplained weight loss, night sweats, swollen lymph nodes, joint pain, or dry mouth, this test can help diagnose the underlying cause2.
Monitoring Treatment:
For patients undergoing treatment for sarcoidosis or related conditions, this test helps monitor the effectiveness of therapy2.
Symptoms That Might Prompt This Test:
Fatigue
Fever
Unexplained weight loss
Night sweats
Swollen lymph nodes
Joint pain
Dry mouth
Lifestyle and Management:
Depending on your results, your healthcare provider might recommend further tests, treatments, or lifestyle changes to manage ACE levels effectively2.
Regular monitoring and follow-up are essential for successful treatment