Understanding the TTG (Tissue Transglutaminase) Test
What It Is:
The TTG (Tissue Transglutaminase) Test, also known as the tTG-IgA test, IgA anti-tissue transglutaminase, IgA Anti-tTG, Celiac disease testing, Celiac disease antibody testing is a blood test used to diagnose celiac disease. It measures the level of antibodies (immunoglobulins) produced by the immune system in response to gluten.
Celiac disease is an autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, barley, and rye.
Why It's Done:
Diagnosing Celiac Disease:
Helps identify the presence of anti-tTG antibodies, which are commonly found in individuals with celiac disease.
Assists in diagnosing dermatitis herpetiformis, a skin condition associated with celiac disease.
Monitoring Health:
Used to monitor the effectiveness of a gluten-free diet in individuals with celiac disease.
Helps evaluate symptoms such as chronic diarrhea, bloating, abdominal pain, and unexplained weight loss.
How the Test Works:
Procedure:
A healthcare professional will take a blood sample from a vein in your arm using a small needle.
The blood sample is collected into a test tube or vial and sent to a laboratory for analysis.
The procedure is usually quick and relatively painless, with results typically available within a few days.
Understanding the Results:
Positive Findings:
Presence of anti-tTG antibodies indicates an increased likelihood of celiac disease.
Negative Findings:
Absence of anti-tTG antibodies suggests a lower likelihood of celiac disease, but further tests may be needed to confirm the diagnosis.
Why Your Doctor Might Order This Test:
Symptoms of Celiac Disease:
If you have symptoms such as chronic diarrhea, bloating, abdominal pain, or unexplained weight loss, this test can help diagnose the underlying cause.
Monitoring Treatment:
For patients undergoing treatment for celiac disease, this test helps monitor the effectiveness of a gluten-free diet.
Symptoms That Might Prompt This Test:
Chronic diarrhea
Bloating
Abdominal pain
Unexplained weight loss
Lifestyle and Management:
Depending on your results, your healthcare provider might recommend further tests, treatments, or lifestyle changes to manage celiac disease effectively.
Regular monitoring and follow-up are essential for successful treatment.